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ross (jason schwartzman) is a customer of spider mike (john leguizamo), a methamphetamine dealer. spider mike and his girlfriend cookie (mena suvari) are constantly arguing, and ross strikes up a friendship with nikki (brittany murphy), a fellow addict. nikki takes ross to "the cook" (mickey rourke), who supplies spider mike with drugs from a meth lab he has set up in a motel room. the cook gives a small amount of meth to ross in exchange for bringing nikki (his girlfriend) home, and says that he will get in touch with ross if he needs a driver.
back at his apartment, ross gets messages from his mother and his former girlfriend amy, wishing him a happy birthday; amy is also demanding that he pay back the money he owes her. ross, assuming she still loves him, calls her and leaves a message. he then goes to the local strip club while high, leading to an intense ferregraphic hallucination. he takes one of the dancers, april, home and has sex with her after handcuffing and tying her to the bed. as they finish, the cook calls with an emergency regarding nikki's dog. ross, still high, duct-tapes april's eyes and mouth shut to keep her quiet and leaves without releasing her.
while ross and nikki take the dog to the veterinarian, policemen and a tv crew raid the trailer where frisbee lives, falsely believing that a meth lab is located there. they take frisbee and his overweight mother into custody, where they threaten him into cooperation in a drug bust.